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Mathematical Modeling in Nutrition and the Health Sciences - August 14-17, 2006 - Hotel Roanoke - Roanoke, Virginia
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Schedule  

Tentative Schedule and Topics

Workshop Agenda

Monday, Aug. 14
8:00 - 4:00 Pre-Conference Workshop, Modeling Training - Beginner Level

The intent of this session is training for individuals just starting modeling.
Presenters/Trainers: Kim Forsten-Williams (Leader), Mark Hanigan/Chris Palliser (ACSL), Janet Novotny/Ray Boston/Meryl Wastney (SAAM)
  1. Model Construction
    1. Purpose - data analyses vs. predictions
    2. Model Type and Aggregation - 2 example problems, 1 static and 1 dynamic
    3. Assumptions
    4. Balance model
    5. Kinetics
    6. Software choice
    7. Coding
    8. Error checking
  2. Sensitivity Analysis
    1. to parameters
    2. to inputs
Tuesday, Aug. 15
8:00 - 4:00 Pre-Conference Workshop, Modeling Training - All Levels

The focus of this session would be parameter estimation and model evaluation. The target audience are those who attended Day 1 training plus any with some modeling experience.
Presenters/Trainers: Mark Hanigan/Chris Palliser (ACSL), Janet Novotny/Ray Boston/Meryl Wastney (SAAM)
  1. Parameter Estimation
    1. Optimizers
    2. Error Models
    3. Data Weighting
    4. Data Transformations
    5. Solution statistics
  2. Model Evaluation
    1. Residuals vs. Predicted
    2. RMSPE
    3. Residuals vs. Inputs
    4. Residuals vs. Model Parameters
    5. Residuals vs. Time
    6. Runs Analysis

Conference Agenda

Tuesday, Aug. 15
Evening
5:45 Opening Remarks
6:00 Using Static Balance Models to Analyze and Extend Observations (J. France and M. D. Hanigan, U. Guelph and Virginia Tech).
7:00 Dynamic Influence of Habitual Molybdenum Intake on the Kinetics of Molybdenym Disposition (J.A. Novotny, USDA)
Wednesday, Aug. 16
8:00 Use of Stochastic Elements in Models (Dept. of Animal Science, N. St-Pierre, Ohio State Univ.)
9:00 Parameter Estimation using Markov Chain, Monte Carlo Techniques. (Jim Oltjen, Dept. of Animal Sciences, Univ. of California, Davis)
10:00 Break
10:15 Assessment of Model Accuracy and Identifiability (Ray Boston and L. O. Tedeschi; Biostatistics, Univ. of Pennsylvania and Texas A & M University)
11:15 Getting Models to Communicate for Investigating Complex Problems (M. Wastney, Dept. of Nutrition, Purdue Univ.)
12:15 Lunch (on your own)
1:15 Selenium and Cancer Prevention: Modeling the Effects of Supplementation (B. Patterson, NIH)
2:15 The Intersection Of Gene Expression With Classical Enzyme Kinetics And Thermodynamics. R. A. Kohn, Dept. of Animal Sciences, University of Maryland.
3:15 Break
3:30 Effect Of Genetic Polymorphisms on the Kinetics of In Vivo Human Folate Metabolism. (A. J. Clifford, Dept. of Nutrition, Univ. of California, Davis)
4:30 Poster Session
7:00 Dinner (on your own)
Thursday, Aug. 17
8:00 The Application of Isotopomer Data and Mathematical Modeling in Flux Quantification. (G. Sriram, Department of Human Genetics and Chemical Engineering, Univ. of California, Los Angeles)
9:00 Integration of Micro-Array and Metabolic Data. (C. Chan, Chemical Engineering and Materials Science, Michigan State Univ.).
10:00 Break
10:15 Balances In Cellular Metabolism And Energetics: Principles In Modeling. J. B. Bassingthwaighte, Dept. of Bioengineering, Univ. of Washington.
11:15 Consideration of Individual Diversity in Predicting Population Nutrient Requirements? (C. Pomar, Agriculture and Agri-Food Canada, Lennoxville)
12:15 Lunch (on your own)
1:15 Applications of Mathematical Modeling in Pediatric Studies of Bone Turnover (Kim O'Brien)
2:15 Use of perturbation models to determine underlying kinetics/dynamics responsible for system changes. Mike Green (Dept. of Nutrition, Penn. State)
3:15 Closing Remarks
3:30 Conference Adjourned


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